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- The Korean War M*A*S*H unit veteran operates as Chief Surgeon in a major city hospital with his colleagues.
- An outdoorsman and a city-bred lawyer team up to fight crime in San Francisco.
- 1979–19861h7.8 (13)TV EpisodeThe new acting board chairman tries to pressure Arnold Slocum into retirement only four months short of his pension.
- A young man admitted to the hospital following an accident informs the staff that his name is "42" and that he is an alien who is stranded on Earth. While building a transmitter to contact his home planet, 42 befriends a sick and lonely woman.
- There is plenty of excitement at the hospital for the opening of the day care center. However, the excitement is short-lived when a child is injured in a fall and it is found out that the day care director was once in a mental institution.
- Trapper's busy hospital schedule becomes even more hectic when family problems crowd in. Melanie arrives to inform him the their daughter Kim is planning to drop out of school.
- When an eight-month-old baby is brought to the hospital with respiratory problems, x-rays show that the child is a dwarf.
- Jackpot convinces several of the staff to invest in a promising young boxer he is managing, but after the fighter kills his opponent in his first professional match he begins to suffer mysterious injuries that may keep him out of the ring permanently.
- Trapper's contract is up for renewal, and a jealous surgeon is trying to discredit him and take over his position as Chief of Surgery.
- Someone is killing terminally ill patients at San Francisco Memorial, and it appears to be an inside job. A young woman with chronic pain is learning how to deal with it, but maybe not soon enough.
- The doctors of San Francisco Memorial find themselves under the glare of a productivity analyst whose desire to get more work from staff leads her to bring back a doctor suspended for operating unnecessarily.
- A baby admitted to the hospital for a urinary tract infection turns out to be a hermaphrodite, sparking a battle between the parents over which sex it should be.
- Trapper fears an epidemic after the leader of a research project becomes mysteriously ill.
- There is a bomb somewhere in the hospital set to go off at midnight, the night of Trapper's 10th anniversary as chief of surgery. The bomb squad can't find it, and the man who planted it is dying from bullet wounds.
- Seventeen-year-old Dr. Elliot Schweitzer is a new intern at SFMH. He takes his work very seriously, pushing himself to the limit. Trapper tries to help him remember that there is more to medicine than science and books.
- A couple desperate for a child adopts a black-market baby, only to discover that the infant is addicted to heroin and has a heart condition. Stanley recruits Trapper and Gonzo to join him in a relay race against Bay General.
- Riverside comes under fire after he takes over one of Gonzo's patients who happens to be dating his father and she ends up almost dying from an allergic reaction to fluorine.
- A 74-year-old woman who is admitted with a blocked artery in her leg has another problem - she is hooked on prescription medications. When Trapper and Gonzo discover that her doctor is responsible, and treats all his patients the same way, they plot to drive him out of business.
- A rumor that Trapper may be leaving SFM for a hospital in Boston has several other staff considering new positions. After 72 hours on duty and the loss of a patient, Stanley is displaying psychotic symptoms, and ends up in jail.
- San Francisco Memorial Hospital is endeavouring to put into place a co-operative care program, due to Arnold Slocomb and the Board of Directors' budget cuts. Mrs Fitch and her niece, Liza, are the perfect candidates, if Mrs. Fitch would only accept Liza's help.
- Gonzo and Trapper are unsure how to treat a college student who has gotten mysteriously sick while doing a research paper on satanic rituals.
- A mentally disabled man who works at the hospital is able to make friends with a crotchety old hermit who is dying of cancer, but gets embarrassed and quits his job when he misinterprets Gloria's feelings for him.
- When an employee from a local nuclear power plant is admitted to SFM with signs of radiation poisoning, Gonzo cannot understand why it appears that nothing is being done to protect other workers from exposure. Meanwhile, Riverside must contend with a very distrusting Gypsy.
- Jackpot is put in charge of Emergency Services while Trapper, Gonzo and Stanley attend a medical conference in Mexico. South of the border, Trapper falls in love with another doctor, but they may have too much in common for the romance to last.
- When Melanie's mother comes for a surprise visit, Trapper learns that Melanie has kept their divorce a secret from her for the last six years. Gonzo suggests that a doctor should work as a nurse for a week to get a better idea of the problems they are having, and he gets volunteered for the job.
- Trapper and Gonzo go on a trip to a cabin which becomes an adventure when an earthquake hits and the woman staying at the cabin needs serious medical care. At the hospital, Riverside leads the evacuation when the earthquake hits.
- Against his better judgement, Trapper agrees to staple the stomach of an obese woman. Gonzo goes to unusual lengths to save Andrea's dog.
- Gonzo and Trapper try to track down the family of a 10-year old girl who was hit by a car and is exhibiting erratic behavior. The only leads they have are gang members with whom she was living with.
- Trapper and Gonzo deal with a deranged Vietnam vet, while Stanley tries to save on taxes by incorporating himself.
- A brilliant surgeon begins suffering from bouts of forgetful and disoriented behavior.
- When Gonzo starts dating a high society woman she tries to convince set up his own private practice and into selling the "Titanic" to Jackpot.
- A surgeon and friend of Trapper comes to operate on someone he knows. But he's experiencing having visions of actual things. He is told that because of head trauma he sustained, he has gained a sixth sense which he doesn't believe in. And it also causes tension between him and his wife, and she turns to Gonzo whom she knows for solace.
- A controlling millionaire publisher gives the hospital a large donation in exchange for Gonzo watching over his daughter who has a rare blood disorder that needs round-the-clock care and is smitten with Dr. Gates. Trapper must find a replacement for Starch who has gotten married and retired.
- With Gonzo accused of sexual misconduct, the hospital faces a public relations nightmare.
- Gloria's brother Brian flies in from Texas for a visit. He manages to turn Gloria's life upside down. As a result of his drinking problem, her work at the hospital suffers and she is given an official warning. Meanwhile, a patient is trying to set Trapper up with her daughter.
- A man is brought in who claims to be writing a book on the KKK. Later someone comes and sees him and threatens him. When Gonzo tries to talk to him about what he said, he denies it. Later Gonzo finds in his things that he's telling the truth and that one of the hospital's brilliant doctors is the head.
- A shy and clumsy nurse asks Trapper for advice on how to attract Gonzo. A woman who is obsessed with her appearance is reluctant to have a tumor in her face removed.
- Gloria falls for a man in a wheelchair - who happens to already have a wife. Gonzo firmly believes that he can cure a disabled man with surgery, but said patient is against the operation. Trapper resents Starch labelling him "predictable", and decides to do something about it.
- An emotionally troubled musician is released much too early from the hospital. Nurse Shoop suffers a hearing loss.
- Gonzo and the staff decide to start a hot-line for people to anonymously call with their problems. Trapper takes a risk by bringing in a retired doctor with an alcohol problem to help perform a rare eye operation.
- Trapper questions Ernie's motives when she accepts a proposal from a long-time suitor only after she finds out that he is dying.
- A professional skater refuses treatment for a heart condition that could be fatal. Stanley and E.J. find out that they are going to be parents.
- At first Trapper is not concerned when an old friend starts to behave erratically, but Gonzo suspects that something is wrong, especially when the doctor freezes during an emergency. Meanwhile, San Francisco Memorial is flooded with patients from a nearby hospital, after it is damaged by fire.
- 1979–19861h7.5 (13)TV EpisodeA female prisoner gives birth to a premature baby, who is rushed to SFM for care. The mother, upset at not being allowed to be with her child, beats the prison warden who refused to arrange for her to be taken to the hospital.
- When Gloria Brancusi learns that Andrea, the orphan girl, has come back to the hospital as a patient her first reaction is to run away. Gloria has second thoughts after deciding to adopt the troubled orphan.
- Trapper lets his imagination run wild when vintage medical equipment stored in his office makes him wonder how doctors in 1917 dealt with issues considered routine in the 1980s.
- Gonzo is suspicious of a young Korean man who comes to the hospital claiming to be the long-lost son of Trapper. A woman with a history of faking illness is surprised when she is diagnosed with a rare disease.
- A man who needs a bone marrow transplant to survive claims that he has no relatives that can serve as donors. However, Gonzo soon discovers that the truth is a little more complicated: the man is in the Witness Protection Program, and cannot safely have contact with his family.
- Hub Wendover arrives at San Francisco Memorial Hospital for treatment for his leg and to be close to his son, Gonzo. Trapper operates on Hub finding his body riddled with cancer. Gonzo and Hub have some issues to deal with. Gonzo can't help but love the Father that supposedly walked out when he was four years old.
- A woman who devotes her life to getting teenage hookers off the street is badly beaten by a pimp. Gonzo's disgust at their apparent disinterest convinces the girls to get revenge on the attacker, while having two prostitutes show up at his house seriously hampers Trapper's love life.