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- CreatorChris CarterStarsDavid DuchovnyGillian AndersonMitch PileggiTwo F.B.I. Agents, Fox Mulder the believer and Dana Scully the skeptic, investigate the strange and unexplained, while hidden forces work to impede their efforts.
- CreatorJoss WhedonStarsSarah Michelle GellarNicholas BrendonAlyson HanniganA young woman, destined to slay vampires, demons and other infernal creatures, deals with her life fighting evil, with the help of her friends.
- CreatorRob ThomasStarsKristen BellJason DohringEnrico ColantoniAfter her best friend is murdered, and her father is removed as county Sheriff, Veronica Mars dedicates her life to cracking the toughest mysteries in the affluent town of Neptune.
- CreatorEric BressJ. Mackye GruberStarsMatt DallasMarguerite MacIntyreBruce ThomasA family takes in a formerly institutionalized teen savant who is missing standard human behaviors such as anger, joy, and love.
- CreatorBill LawrenceStarsZach BraffDonald FaisonSarah ChalkeIn the unreal world of Sacred Heart Hospital, intern John "J.D." Dorian learns the ways of medicine, friendship and life.
- CreatorDavid GreenwaltJoss WhedonStarsDavid BoreanazCharisma CarpenterAlexis DenisofThe vampire Angel, cursed with a soul, moves to Los Angeles and aids people with supernatural-related problems while questing for his own redemption.
- CreatorRené EchevarriaScott PetersStarsJacqueline McKenzieJoel GretschPatrick John FluegerAs the reappearance of 4,400 missing persons on a single day confounds the global community, federal agents on the case slowly discover the ways in which the victims have been changed.
- CreatorAmy Sherman-PalladinoStarsLauren GrahamAlexis BledelKeiko AgenaA dramedy centering around the relationship between a thirtysomething single mother and her teen daughter living in Stars Hollow, Connecticut.
- CreatorRon KoslowTrevor MunsonStarsAlex O'LoughlinSophia MylesJason DohringAn immortal vampire and private investigator struggles to exist after he was bitten 60 years ago by his vampire bride. He is also internally tormented as he falls in love with one he should not.
- CreatorMichele AbbottIlene ChaikenKathy GreenbergStarsJennifer BealsLeisha HaileyLaurel HollomanFollows the lives and loves of a small, close-knit group of lesbian women living in Los Angeles as well as the friends and family members that either support or loathe them.
- CreatorShonda RhimesMichelle LirtzmanStarsEllen PompeoChandra WilsonJames Pickens Jr.A drama centered on the personal and professional lives of five surgical interns and their supervisors.
- CreatorEric KripkeStarsJared PadaleckiJensen AcklesJim BeaverTwo brothers follow their father's footsteps as hunters, fighting evil supernatural beings of many kinds, including monsters, demons, and gods that roam the earth.
- CreatorAri SchlossbergStarsElaine CassidyChristopher GorhamMatt BarrHarper's Island was once the scene of a gruesome series of murders. Seven years later, family and friends gather on the island for a wedding, but one by one they begin to die.
- CreatorJames CameronCharles H. EgleeStarsJessica AlbaMichael WeatherlyRichard GunnA group of genetically-enhanced children escape from a lab project. Years later we meet Max, one of the escapees who now works for a messenger service in the post-apocalyptic Pacific Northwest.
- CreatorAlan BallStarsAnna PaquinStephen MoyerSam TrammellTelepathic waitress Sookie Stackhouse encounters a strange new supernatural world when she meets the mysterious Bill Compton, a southern Louisiana gentleman and vampire.
- CreatorAlan BallStarsPeter KrauseMichael C. HallFrances ConroyA chronicle of the lives of a dysfunctional family who run an independent funeral home in Los Angeles.
- StarsPeter KrauseJulianna MarguliesPeter JacobsonA detective investigates a mysterious motel room which acts as a portal to anywhere in the world.
- CreatorConstance M. BurgeStarsHolly Marie CombsAlyssa MilanoBrian KrauseThree Halliwell sisters discover that they are descendants of a line of good female witches and are destined to fight against the forces of evil, using their combined power of witchcraft known as the "Power of Three".
- CreatorStephen KingStarsJamie HarroldDiane LaddBruce DavisonThe quirky staff and patients of an ultramodern (albeit increasingly dilapidated) Maine hospital gradually become familiar with the supernatural occurrences that take place there, uncovering a dark secret in the process.
- CreatorBrent V. FriedmanBryce ZabelStarsEric CloseJ.T. WalshLackosIn 1960s America, a young couple struggle to expose the truth about a hidden alien invasion, while a secret government organization follows its own agenda in dealing with the threat.
- CreatorLeslie StevensStarsKevin ConwayAlex DiakunEric Schneider"The Outer Limits" is a science fiction anthology series, with Kevin Conway providing the voice of "Control Voice".
- CreatorTim KringStarsJack ColemanHayden PanettiereMilo VentimigliaCommon people discover that they have super powers. Their lives intertwine as a devastating event must be prevented.
- CreatorCarol BlackNeal MarlensDavid S. RosenthalStarsEllen DeGeneresDavid Anthony HigginsJoely FisherEllen Morgan is a neurotic bookstore owner who deals with life through comedy and extensive rambling.
- CreatorDavid E. KelleyStarsCalista FlockhartGreg GermannJane KrakowskiFollows the personal and professional life of lawyer Ally.
- CreatorAndrew CosbyJaime PagliaStarsColin FergusonSalli Richardson-WhitfieldErica CerraA U.S. Marshal becomes the sheriff of Eureka, a remote, cozy little Northwestern town where the best minds in the US have secretly been tucked away to build futuristic inventions for the government which often go disastrously wrong.