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- DirectorDeran SarafianStarsEric McCormackRachael Leigh CookKelly RowanPierce tries to crack a coded message left in a newspaper.
- DirectorDeran SarafianStarsEric McCormackRachael Leigh CookKelly RowanThe FBI is trying to find a serial killer who was last active 26 years who appears to be active again. One of his victims from 26 years ago was so traumatized that she was placed in a psych ward. But Daniel thinks that the doctors misdiagnosed her and that she can help them. Problem is that she thinks it's 26 years ago and that she's still a teen.
- DirectorAlan PoulStarsEric McCormackRachael Leigh CookKelly RowanDr. Daniel Pierce is an eccentric neuroscientist who uses his unique outlook to help the federal government solve complex criminal cases.
- DirectorGreg BeemanStarsEric McCormackRachael Leigh CookKelly RowanMoretti enlists Pierce's help to solve a murder of a mail-order bride.
- DirectorChristopher MisianoStarsEric McCormackRachael Leigh CookKelly RowanA young man in a cult claims to be hearing the word of God.
- DirectorGreg BeemanStarsEric McCormackRachael Leigh CookKelly RowanPierce helps the FBI investigate the murder of a therapist.
- DirectorChristopher MisianoStarsEric McCormackRachael Leigh CookKelly RowanKate wants to impress a new boss and asks Dan to evaluate a young man who's been accused of stalking a federal judge. The judge earlier remanded the young man for treatment as a schizophrenic. When Daniel evaluates the kid as harmless only to have the judge stabbed to death hours later, Kate is told to leave the case alone but Daniel is convinced that the kid is not responsible.
- DirectorTawnia McKiernanStarsEric McCormackRachael Leigh CookKelly RowanMoretti and Pierce investigate the murder of a college student.
- DirectorKenneth BillerStarsEric McCormackRachael Leigh CookKelly RowanPierce is tipped off about a conspiracy to cover the murder of a Senator.
- DirectorKenneth BillerStarsEric McCormackRachael Leigh CookKelly RowanMoretti learns there may be some truth to Pierce's conspiracy theory.
- DirectorGreg BeemanStarsEric McCormackRachael Leigh CookKelly RowanPierce is hired to determine the competency of a convicted murderer who has been granted a new trial. After examining the killer, who had subsequently suffered a brain injury and now exhibits a completely changed personality, Pierce asserts that he is essentially no longer the same person and should no longer be held accountable for the murder. His work puts him at odds with the new prosecutor Donnie Ryan, who doesn't like the fact that Pierce is interfering with his case, or that he is such good friends with Kate, his soon to be ex-wife.
- DirectorGreg BeemanStarsEric McCormackRachael Leigh CookKelly RowanA woman becomes convinced that her husband is no longer really her husband. When it appears she has murdered him she claims she really didn't kill her husband - only his alien impostor.
- DirectorJeff WoolnoughStarsEric McCormackRachael Leigh CookKelly RowanPierce consults on a case in a small town where teenage girls are suddenly displaying symptoms of Tourette's Syndrome. If it isn't from environmental poisoning or a bacterial infection it may be from collective guilt over a tragic incident.
- DirectorChristopher MisianoStarsEric McCormackRachael Leigh CookKelly RowanIn order to get information on a murder suspect, Daniel and Kate have to go undercover in an online gaming community. But being immersed in an imaginary universe is hardly the place for a schizophrenic like Daniel.
- DirectorAndrew BernsteinStarsEric McCormackRachael Leigh CookKelly RowanParkinson patients start dying from defective implants used to control their symptoms. But even as he realizes the "malfunctions" may be a cover-up to murder, he also wonders if the miracle device could be a cure to his schizophrenia.
- DirectorAndrew BernsteinStarsEric McCormackRachael Leigh CookKelly RowanMoretti calls on Pierce to determine the credibility of a man's death-bed confession; Pierce and Moretti try to uncover the truth about a series of apparent homicides.
- DirectorGreg BeemanStarsEric McCormackRachael Leigh CookKelly RowanDaniel agrees to help a woman accused of killing a nurse in a state hospital even though it means going undercover inside an asylum. Once he's inside, his own hallucination has to compete against something the patients call "Creek".
- DirectorKenneth BillerStarsEric McCormackRachael Leigh CookKelly RowanAfter a decorated war hero is arrested for destroying a convenience store, Daniel believes her erratic behavior is the result of an infection that produced swelling in her brain. Kate convinces Donnie not to prosecute her. After she is implicated in the deaths of two of her fellow soldiers, Kate begins to regret her actions until the soldier accuses a Congressman's son (her platoon sergeant in Afghanistan) of rape. Kate makes it her mission to see that he is brought to justice. However, in her zeal to get him she may go too far and end her career.
- DirectorKenneth BillerStarsEric McCormackRachael Leigh CookKelly RowanIn the conclusion of "Wounded", Kate goes on trial for the death of Sgt. Rickford. Donnie resigns his job to become her defense attorney even though Kate begins to doubt her own account of events and thinks she may in fact be guilty.
- DirectorGreg BeemanStarsEric McCormackRachael Leigh CookKelly RowanAn autistic boy obsessed with trains, appears to have killed a security guard when he unexpectedly moved a train. Pierce realizes he actually prevented a railroad collision and that the dead guard may have been the victim of someone else.
- DirectorChristopher MisianoStarsEric McCormackRachael Leigh CookKelly RowanMax Lewicki's estranged 16 year old brother shows up at Pierce's house one step ahead of the law. He eventually confesses to a murder but Pierce thinks that he only imagined it and tries to find the real killer.
- DirectorChristopher MisianoStarsEric McCormackRachael Leigh CookKelly RowanPierce receives a tip that the CIA might be assassinating U.S. citizens; one of Pierce's close friends is murdered; Moretti tries to overcome her trust issues.
- DirectorChristopher MisianoStarsEric McCormackRachael Leigh CookKelly RowanPierce's academic career is threatened when he hallucinates in class. Meanwhile, he, Moretti, and a RCMP officer track a serial killer who is stalking Pierce's former therapist. In the end, both he and Moretti face life-altering decisions.
- DirectorKenneth BillerStarsEric McCormackRachael Leigh CookKelly RowanIn the season three premiere, Dr. Pierce is approached by the FBI to help with a dangerous international case. Plus, Max Lewicki and Dean Paul Haley plot to get Pierce to return to Chicago.
- DirectorEric McCormackStarsEric McCormackRachael Leigh CookKelly RowanPierce and Moretti search for a killer when a prosecutor dies in the middle of a courtroom; Moretti and Donnie make some decisions about their future.