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- DirectorDennis HopperStarsPeter FondaDennis HopperJack NicholsonTwo bikers head from L.A. to New Orleans through the open country and desert lands, and along the way they meet a man who bridges a counter-culture gap of which they had been unaware.
- DirectorJerry SchatzbergStarsAl PacinoKitty WinnAlan VintFollows the lives of heroin addicts who frequent "Needle Park" in New York City.
- DirectorAlan ParkerStarsBrad DavisIrene MiracleBo HopkinsBilly Hayes, an American college student, is caught smuggling drugs out of Turkey and thrown into prison.
- DirectorUli EdelStarsNatja BrunckhorstEberhard AurigaPeggy BussieckA teen girl in 1970s Berlin becomes addicted to heroin. Everything in her life slowly begins to distort and disappear as she befriends a small crew of junkies and falls in love with a drug-abusing male prostitute.
- DirectorGus Van SantStarsMatt DillonKelly LynchJames Le GrosA pharmacy-robbing dope fiend and his crew pop pills and evade the law.
- DirectorRichard LinklaterStarsJason LondonWiley WigginsMatthew McConaugheyThe adventures of high school and junior high students on the last day of school in May 1976.
- DirectorDanny BoyleStarsEwan McGregorEwen BremnerJonny Lee MillerRenton, deeply immersed in the Edinburgh drug scene, tries to clean up and get out despite the allure of drugs and the influence of friends.
- DirectorGuy RitchieStarsJason FlemyngDexter FletcherNick MoranEddy persuades his three pals to pool money for a vital poker game against a powerful local mobster, Hatchet Harry. Eddy loses, after which Harry gives him a week to pay back 500,000 pounds.
- DirectorTerry GilliamStarsJohnny DeppBenicio Del ToroTobey MaguireAn oddball journalist and his psychopathic lawyer travel to Las Vegas for a series of psychedelic escapades.
- DirectorDarren AronofskyStarsEllen BurstynJared LetoJennifer ConnellyThe drug-induced utopias of four Coney Island people are shattered when their addictions run deep..
- DirectorSteven SoderberghStarsMichael DouglasBenicio Del ToroCatherine Zeta-JonesA conservative judge is appointed by the President to spearhead America's escalating war against drugs, only to discover that his teenage daughter is a crack addict. Two DEA agents protect an informant. A jailed drug baron's wife attempts to carry on the family business.
- DirectorTed DemmeStarsJohnny DeppPenélope CruzFranka PotenteThe story of how George Jung, along with the Medellín Cartel headed by Pablo Escobar, established the American cocaine market in the 1970s in the United States.
- DirectorMatthew VaughnStarsDaniel CraigSienna MillerMichael GambonA successful cocaine dealer gets two tough assignments from his boss on the eve of his planned early retirement.
- CreatorDavid SimonStarsDominic WestLance ReddickSonja SohnThe Baltimore drug scene, as seen through the eyes of drug dealers and law enforcement.
- CreatorVince GilliganStarsBryan CranstonAaron PaulAnna GunnA chemistry teacher diagnosed with inoperable lung cancer turns to manufacturing and selling methamphetamine with a former student in order to secure his family's future.
- DirectorGaspar NoéStarsNathaniel BrownPaz de la HuertaCyril RoyAn American drug dealer living in Tokyo is betrayed by his best friend and killed in a drug deal. His soul, observing the repercussions of his death, seeks resurrection.
- DirectorJon S. BairdStarsJames McAvoyJamie BellEddie MarsanA corrupt, junkie cop with bipolar disorder attempts to manipulate his way through a promotion in order to win back his wife and daughter while also fighting his own inner demons.
- DirectorMatthew HeinemanStarsTim FoleyJosé Manuel 'El Doctor' MirelesPaco ValenciaFilmmaker Matthew Heineman examines the state of the ongoing drug problem along the U.S.-Mexican border.
- DirectorBernard RoseStarsRhys IfansChloë SevignyDavid ThewlisThe life story of Howard Marks, an elite British drug smuggler.
- DirectorYann DemangeStarsMatthew McConaugheyRichie MerrittBel PowleyThe story of teenager Richard Wershe Jr., who became an undercover informant for the FBI during the 1980s and was ultimately arrested for drug-trafficking and sentenced to life in prison.