As his kingdom is being threatened by the Turks, young prince Vlad Tepes must become a monster feared by his own people in order to obtain the power needed to protect his own family, and the families of his kingdom.
Selene, a vampire warrior, is entrenched in a conflict between vampires and werewolves, while falling in love with Michael, a human who is sought by werewolves for unknown reasons.
Picking up directly from the previous movie, vampire warrior Selene and the half werewolf Michael hunt for clues to reveal the history of their races and the war between them.