When the Conclave is destroyed, leaving only one survivor, demons are loosed up on the world. In an attempt to restore order and save the world, the survivor--now the inquisitor-- instigates the long forgotten inquisition.
While investigating the scene of a cruel murder, detective Sebastian Castellanos is knocked unconscious by a mysterious and powerful force. When he awakens, he finds himself in a deranged world.
When Jeanne's soul is dragged into the depths of Inferno after a demon summoning goes horribly wrong, Bayonetta goes on a dangerous quest to Inferno to rescue her friend before its too late.