As a modern-day scientist, Tommy is struggling with mortality, desperately searching for the medical breakthrough that will save the life of his cancer-stricken wife, Izzi.
A young man in a small Midwestern town struggles to care for his mentally-disabled younger brother and morbidly obese mother while attempting to pursue his own happiness.
After a car wreck on Mulholland Drive renders a woman amnesiac, she and a Hollywood-hopeful search for clues and answers across Los Angeles in a twisting venture beyond dreams and reality.
A camera-eye is aimed at David Lynch's back while in Hanover a second one records the internet-stream, which connects the continents. a third one shoots parallely Agnieszka Jurek. she is interviewing Mr. Lynch.