After the devastating events of Avengers: Infinity War (2018), the universe is in ruins. With the help of remaining allies, the Avengers assemble once more in order to reverse Thanos' actions and restore balance to the universe.
After being bitten by a genetically-modified spider, a shy teenager gains spider-like abilities that he uses to fight injustice as a masked superhero and face a vengeful enemy.
In a world where mutants (evolved super-powered humans) exist and are discriminated against, two groups form for an inevitable clash: the supremacist Brotherhood, and the pacifist X-Men.