A team of miners at an outpost in deep space unearth an ancient alien artefact. After the relic is brought aboard their spaceship, the USG Ishimura, for scientific study, an alien species begins to infect the members of the ship.
Four survivors aboard the spaceship USG O'Bannon, the first responder ship sent to rescue the members of the USG Ishimura, try to recall the horrific events that wiped out their crew.