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- CreatorDavid CraneMarta KauffmanStarsJennifer AnistonCourteney CoxLisa KudrowFollows the personal and professional lives of six twenty to thirty year-old friends living in the Manhattan borough of New York City.
- CreatorChuck LorreBill PradyStarsJohnny GaleckiJim ParsonsKaley CuocoA woman who moves into an apartment across the hall from two brilliant but socially awkward physicists shows them how little they know about life outside of the laboratory.
- CreatorLarry DavidJerry SeinfeldStarsJerry SeinfeldJulia Louis-DreyfusMichael RichardsThe continuing misadventures of neurotic New York City stand-up comedian Jerry Seinfeld and his equally neurotic New York City friends.
- CreatorCarter BaysCraig ThomasStarsJosh RadnorJason SegelCobie SmuldersA father recounts to his children - through a series of flashbacks - the journey he and his four best friends took leading up to him meeting their mother.
- CreatorLee AronsohnChuck LorreStarsJon CryerAshton KutcherAngus T. JonesA hedonistic jingle writer's free-wheeling life comes to an abrupt halt when his brother and 10-year-old nephew move into his beach-front house.
- CreatorDavid AngellPeter CaseyDavid LeeStarsKelsey GrammerJane LeevesDavid Hyde PierceDr. Frasier Crane moves back to his hometown of Seattle, where he lives with his father and works as a radio psychiatrist.
- CreatorJames BurrowsGlen CharlesLes CharlesStarsTed DansonRhea PerlmanJohn RatzenbergerThe regulars of the Boston bar "Cheers" share their experiences and lives with each other while drinking or working at the bar where everybody knows your name.
- CreatorGemma BakerEddie GorodetskyChuck LorreStarsAllison JanneyAnna FarisMimi KennedyA newly sober single mom tries to pull her life together in Napa Valley while dealing with her wayward mother.
- CreatorPhil RosenthalStarsRay RomanoPatricia HeatonBrad GarrettThe comical everyday life of sports columnist Ray Barone and his dysfunctional family.
- CreatorDavid LittMichael J. WeithornStarsKevin JamesLeah ReminiJerry StillerDeliveryman Doug Heffernan has a good life: He has a pretty wife (Carrie), a big television, and friends with which to watch it. Then Carrie's goofy, annoying father Arthur moves in with them.
- CreatorDavid KohanMax MutchnickStarsEric McCormackDebra MessingMegan MullallyGay lawyer Will and straight interior designer Grace share a New York City apartment. Their best friends are gleeful and proud gay Jack and charismatic, filthy-rich, amoral socialite Karen.
- CreatorSteven LevitanStarsLaura San GiacomoEnrico ColantoniGeorge SegalHot-tempered journalist Maya got herself fired yet again. Unable to find a job anywhere else and facing eviction, she is forced to go work for Blush, her father's fashion magazine.
- CreatorGerry DeeMichael VolpeStarsGerry DeeJonathan TorrensLauren HammersleyFollows a teacher juggle through being a teacher and deal with his students while trying to maintain his not so cool lifestyle.
- CreatorKevin BiegelBill LawrenceStarsCourteney CoxChrista MillerBusy PhilippsFollows the escapades and relationships of a group of neighbors living in Gulfhaven, Florida.
- CreatorEileen HeislerDeAnn HelineStarsPatricia HeatonNeil FlynnCharlie McDermottThe daily mishaps of a married woman and her semi-dysfunctional family and their attempts to survive life in general in the town of Orson, Indiana.
- CreatorSteven LevitanChristopher LloydStarsEd O'NeillSofía VergaraJulie BowenThree different, but related, families face trials and tribulations in their own uniquely comedic ways.
- CreatorMark BrazillBonnie TurnerTerry TurnerStarsTopher GraceLaura PreponMila KunisA comedy revolving around a group of teenage friends, their mishaps, and their coming of age, set in 1970s Wisconsin.
- CreatorRon LeavittMichael G. MoyeStarsEd O'NeillChristina ApplegateKatey SagalAl is the quintessential working class dad. Peggy, his wife, always wants more from him. With their children, they go through the highs and lows of ordinary life.
- CreatorSusan HarrisStarsBea ArthurBetty WhiteRue McClanahanFour previously married women live together in Miami, sharing their various experiences together and enjoying themselves despite hard times.
- StarsChris O'DowdRichard AyoadeKatherine ParkinsonThe comedic misadventures of Roy, Moss and their grifting supervisor Jen, a rag-tag team of IT support workers at a large corporation headed by a hotheaded yuppie.
- CreatorDylan MoranStarsDylan MoranBill BaileyTamsin GreigBernard Black runs a book shop, though his customer service skills leave something to be desired. He hires Manny as an employee. Fran runs the shop next door. Between the three of them many adventures ensue.
- CreatorDavid CraneJeffrey KlarikStarsMatt LeBlancStephen ManganTamsin GreigA couple of British TV producers move to Hollywood to export their most popular series, and find it is not what they expected.
- StarsJack DavenportGina BellmanSarah AlexanderSix best friends talk about all aspects of sex and relationships on their never-ending quest to find true love.
- StarsMiranda HartPatricia HodgeTom EllisSocially inept Miranda always gets into awkward situations; working in her joke shop with best friend Stevie, being hounded by her pushy mother, and around her crush Gary.
- CreatorJesse ArmstrongSam BainAndrew O'ConnorStarsDavid MitchellRobert WebbMatt KingMark and Jez are a couple of twenty-something roommates who have nothing in common - except for the fact that their lives are anything but normal. Mayhem ensues as the pair strive to cope with day-to-day life.