Teen Miles Morales becomes the Spider-Man of his universe and must join with five spider-powered individuals from other dimensions to stop a threat for all realities.
With Spider-Man's identity now revealed, Peter asks Doctor Strange for help. When a spell goes wrong, dangerous foes from other worlds start to appear, forcing Peter to discover what it truly means to be Spider-Man.
After Peter Parker is bitten by a genetically altered spider, he gains newfound, spider-like powers and ventures out to save the city from the machinations of a mysterious reptilian foe.