- Was the only Taxi (1978) cast member to attend Andy Kaufman's funeral.
- Longtime close friend of Diane Keaton. They have appeared in three films together: Harry and Walter Go to New York (1976), Annie Hall (1977) and The Lemon Sisters (1989).
- Friend of Bette Davis. Davis once said she'd most like to see Kane portray her in a film biography. Kane portrayed Bette Davis in Craig Lucas' 2013 play, the Lying Lesson.
- In the 1988 American Christmas comedy, Scrooged (1988) , when Kane grabbed Bill Murray's lip, she did so with such force that it actually injured him, tearing his lip and halting production for a few days.
- A self-professed "Upper West Side gal". She grew up on West 68th Street in the Dorchester Towers, and bought her first studio apartment a block away for $25,000 in the '70s and still lives in the neighborhood.
- Before becoming an actress, as a "survival job", she worked for Backstage magazine putting mailers in envelopes, licking them closed, and putting stamps on them. She held the job even after she acted in The Last Detail (1973).
- She is unmarried and she has no children.
- Was the first and only choice to play Lillian on the Unbreakable Kimmy Schmidt (2015). Tina Fey (the show's writer, alongside Robert Carlock) coached her personally for the role.
- Since 19-years-old she and Anjelica Huston have been close friends. Kane attended the 1992 wedding of Huston and Robert Graham (d. December 27, 2008). For unknown reasons, Kane replaced Judith Malina as Grandmama Addams for the The Addams Family (1991) sequel, Addams Family Values (1993) (both starring Huston as Morticia Addams).
- Does not belong to any social media platforms, and has said that she is "computer-illiterate".
- She has appeared in five films that have been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: Hester Street (1975), Dog Day Afternoon (1975), Annie Hall (1977), The Muppet Movie (1979) and The Princess Bride (1987).
- Besides Richard Belzer, she is the only other actor to play her Homicide: Life on the Street (1993) character (Gwen Munch) in Law & Order: Special Victims Unit (1999).
- Quintessentially a New York actress. Since her theatrical debut in the 1966 production of the Prime of Miss Jean Brodie, has appeared on the New York Stage (both on and Off-Brodway). Plays include Beth Henley's Family Week and The Debutante Ball. She co-starred with Gena Rowlands's in the play A Woman of Mystery directed by John Cassavetes. At Lincoln Center for Joseph Papp her performances include The Tempest and Macbeth as well as plays at Mr. Papp's Public Theatre, including Wasp and Other Plays by Steve Martin. She starred alongside Shelley Winters on Broadway in The Effect of Gamma Rays, on Man-in-the-Moon Marigolds.
- Longtime friend of Mia Farrow.
- Recipient of the 2015 Washington Jewish Film Festival (WJFF) Visionary Award. WJFF founder and former director Aviva Kempner selected Kane for "expertly showcasing the Jewish experience on the silver screen".
- Started her film career as an extra in the Walter Matthau film Plaza Suite (1971). Actress Lee Grant had a starring role in the film, who would later work with Kane in the uniquely dark film, The Mafu Cage (1978). Grant and Kane remain close friends.
- She studied drama at HB Studio in Greenwich Village in New York City.
- As of 2018 has been in two films nominated for Best Picture Oscar: Dog Day Afternoon (1975), and Annie Hall (1977).
- Longtime friend of actress Gena Rowlands. Rowlands played Kane's mother in John Cassavetes 1987 play, "A Woman of Mystery".
- Rates Wedding in White (1972) and Hester Street (1975) as her two best films.
- In addition to appearing with Shelley Duvall in Annie Hall (1977), Kane has appeared in two of Duvall's made-for-TV productions: Sleeping Beauty (1983) and Casey at the Bat (1986).
- Acted in four of the 250 top-US-grossing feature films released 1970-1979': The Muppet Movie (1979) at #39, Gross: $76.66M; Dog Day Afternoon (1975) #52, Gross: $50.00M; Annie Hall (1977) #80, Gross: $39.20M; Carnal Knowledge (1971) #119, Gross: $28.62M, and When a Stranger Calls (1979) #145, Gross: $21.41M.
- Member of the Screen Actors Guild American Federation of Television and Radio Artists (SAG AFTRA) since the '70s. Has been a member since her first movie role, in the film Carnal Knowledge (1971).
- Born on exactly the same date as Isabella Rossellini.
- Is godmother to actress Bianca Hunter. They have appeared in one film together, Trees Lounge. Director Steve Buscemi cast them not knowing of their connection.
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