- In the 1970's, he worked his way through college as a member of the production crew on "Mister Rogers' Neighborhood.".
- Son of Warren Frost. Warren acted in Mark's co-created TV show Twin Peaks (1990).
- Brother of Scott Frost and Lindsay Frost. Scott wrote a few of the episodes.
- Brother-in-law of Rick Giolito.
- Biography/bibliography in: "Contemporary Authors". New Revision Series, Volume 170, pages 123-126. Farmington Hills, MI: Gale, Cengage Learning, 2008.
- Mark Frost & David Lynch were nominated for the 2018 Emmy Award in the Outstanding Writing for a Limited Series, Movie or Special category for Twin Peaks (2017), but lost to William Bridges & Charlie Brooker for USS Callister (2017).
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