- Was the original voice of "Buster Bunny" on Tiny Toon Adventures (1990). He reportedly quit after learning that he was not going to receive a role on the upcoming series, Animaniacs (1993), despite having been the lead on "Tiny Toons" while other actors form the series, such as Rob Paulsen, Maurice LaMarche and Tress MacNeille, were being given roles on Animaniacs (1993), and was further angry when he learned that a prominent role (Wacko) was given to Jess Harnell, who was a relative newcomer to voice acting at the time while Adler himself had much more experience. Adler was replaced by John Kassir, better known as the voice of the "Crypt Keeper" on Tales from the Crypt (1989).
- Was one, of only two, voiceover actors from the original The Transformers (1984) animated series to voice a character in the live action film version Transformers (2007). The other being Peter Cullen. Adler, who voiced the Autobot Silverbolt in the animated series (among others), went on to provide the voice of of the treacherous Decepticon Starscream for the film.
- Since 2007, he has played three roles originally played by the late Chris Latta in new adaptations of the G.I. Joe and Transformers franchises - Starscream, Cobra Commander and Gung-Ho.
- He has dialogue directed one Emmy Award-winning performance: Eartha Kitt in The Emperor's New School (2006).
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