When Polidori introduces Victor to the creature in his carriage, the interior point of view shot shows a Chinese servant closing the carriage door. A split second later, in a reverse angle shot from the exterior, the servant has vanished.
When Victor is talking to Elizabeth outside the church at his brother's funeral, he is holding his right hand on her shoulder. The shot switches to Elizabeth's face, and his hand is still on her shoulder. In the next wide shot, Victor's hand is down by his side. The following closeup of Elizabeth shows Victor's hand back on her shoulder.
When Frankenstein dissolves the severed arm with acid, the arm as first shown at the beginning of the scene is significantly different in appearance than the one which is shown actually being dissolved.
James Mason's narration implies that unlike previous Frankenstein movies, this one will follow Mary Shelley's original story. While the movie includes subplots that were left out of previous adaptations, it still only bears a loose resemblance to what she wrote.
James Mason's prologue depicts Mary Shelley's tombstone next to a busy London street. She is actually buried in a family crypt in Dorset.
The French Countess refers to Sir Richard Fanshawe as "Sir Fanshawe" rather than "Sir Richard." British knights are referred to by the given name rather than the surname.
Characters often pronounce the name Clerval as "Clervel."