Florence Stanley played the character of Judge Wilbur on My Two Dads (1987) and in the crossover episode The Game Show (1989), substituting for Judge Harry Stone. Officer Bull Shannon (Richard Moll) appeared in the episode Playing with Fire (1989), serving as a bodyguard for Judge Wilbur.
On the Season 1 DVD bonus interview, Staci Keanan revealed that after the pilot was filmed, NBC didn't want her for the role of Nicole and wanted to recast her with a different actress. Producer Michael Jacobs favored Keanan and fought for her casting with him eventually getting his way and the network ended up keeping Keanan for the part.
Greg Evigan sings the theme song for the series.
Before being cast as Michael, Paul Reiser was considered for the role of Danny Tanner on Full House (1987).
Well into the airing of the series (perhaps in the 2nd or 3rd season), NBC accidentally aired a promo for a future episode referring to the show by its working title, "Who's Dad?"