Yes, but a sizeable learning curve exists. For starters, Fallout is an isometric true role-playing game. There is no first person mode, and players of Bethesda Fallout games will need to get used to the fact that resources are realistic. That is, not abundant.
Combat is also far more like that of a role-playing game. Levels of skill, difficulties of tasks, and dice rolls all play a part.
If you can get past that, you will take part in a story far better than 3 or 4, and arguably New Vegas to a lesser extent. It is worth it.