Sully's hair is all wrong. It's gone from wavy sunkissed brown to flat straight and grey.
The embroidered cape Colleen is wearing near the 23 min mark is nearly identical to the one Robert E bought for Grace in the series.
In this film, set in 1876 and broadcast in 2001, Brian gets a job at The Boston Globe and Michaela and Sully return to Colorado without him. Brian is living in Colorado in "Dr. Quinn, Medicine Woman: The Movie," which was broadcast in 1999 but set it 1877.
Although Harvard Medical School opened in 1782, the first woman did not graduate there until 1966.
Andrew previously told Colleen he wished his parents were alive to see his wedding. Either he's a colossal liar, or the writers don't know their own material.
In the series finale Andrew said his parents were dead but his father Charles is in this movie along with his mother who were both introduced at Elizabeth Quinn's party.