In the scene where Sully and Dr Mike are trying to decide where the infection could be in the clinic. They are standing in front of the coat hooks by the door. In the first part of the scene there is an "open" sign on the hook. As the scene fades out the sign is no longer hanging in that spot.
Although not known at the time, staph bacteria can live on paper surfaces for 7 days. So burning the books and diplomas may not have been necessary.
It was not explored that the source of contamination could have been the Chinese laundry itself.
When matthew and the townsfolk present dr mike with a new medical bag, a close look at the upper right-hand corner shows a modern white postage sticker.
It is completely unrealistic for Dr. Quinn to burn her office furniture in the center of town. It could have resulted in the entire town burning down.
No man would ask a doctor to remove a splinter. This is especially true if he was spending money for a homestead.
Colleen was in Colorado Springs too long. It would take weeks for the new medical equipment to be ordered and transported to Colorado Springs.
Mr. Jacobs would have family around him at the recovery room in the Clinic.