Sully (Joe Lando) and Cloud Dancing's (Larry Sellers) trip back to Colorado Springs takes a terrifying turn when robbers overtake the train. Sully attempts to defend the train, but cannot prevent it from derailing.
Finally ready to work again after giving birth to her baby, Dr. Michaela "Mike" Quinn (Jane Seymour) faces prejudice when she finds the townspeople prefer being treated by young Dr. Andrew Cook (Brandon Douglas), who filled in for her while she was on maternity leave. For his part, Andrew has become reluctant to return the practice to Mike and go back to Boston, as originally agreed. Word of the train wreck reaches town, and Mike must lead a rescue party.