George Clooney refused to cameo for the funeral scene, stating that his appearance would have overshadowed the farewell to Anthony Edwards.
Mark Greene utters the word "shit" when he falls out of bed, highly unusual for network television.
This episode is Anthony Edwards's final appearance as a regular cast member, although he is still in the opening credits in the next episode. He returned for a guest appearance in 2008.
Eriq La Salle and Michael Michele make cameo appearances in this episode. This is Michele's final appearance in the series.