Cindy's homecoming dress is actually being worn backwards because the front was deemed too revealing.
Neal's line "She's a cheerleader, you've seen Star Wars 27 times. You do the math" came from Samm Levine.
During the credits while Seth Rogen is sitting on the stool, you can see Jason Segel in the background rubbing his eyes to give the impression he was high.
The cinematographer for the pilot was Bill Pope, who also shot The Matrix (1999) shortly before - he moved on to movies after Freaks and Geeks.
Acting debuts of Seth Rogen, Lizzy Caplan & John Francis Daley.