The first time Janice laughs at one of Chandler's jokes, Maggie Wheeler slipped up and let out a shrill, annoying laugh. This was later added to Janice's character.
The first words that Janice utters are "Oh my God" which later became her catch phrase.
Ross's detergent Überweiss is German for "overly white".
In the DVD version of the episode, when Chandler first tells Janice they should break up, she calls him out on his fear of commitment.