Cristina is the first person to call Shepherd "McDreamy".
The flier Meredith posts for roommates says "Two nice rooms with shared bath available immediately, close to Seattle Grace. Near coffee shop, public transportation, shopping, and convenient to almost everything. Non-smokers only please, no pets and absolutely no Bush supporters need apply. All applicants will need to have a credit check completed. First and last month's rent plus a deposit is required to move in."
The song "Wait" performed in this episode by Get Set Go is redone by Actress Chandra Wilson (Bailey) in the Grey's musical event.
Every episode of the show is named after a famous song. "The First Cut is the Deepest" is a song by Cat Stevens.