Matthew Perry is the second main cast member of the NBC sitcom Friends (1994) to have been a guest voice on "The Simpsons." The first was Lisa Kudrow, who provided the voice of Alex Whitney in the season 10 premiere episode Lard of the Dance (1998).
Pierce Brosnan's role was intended for Sean Connery. Whereas at the time of airing, Brosnan was the incumbent actor playing James Bond, Connery was the first actor to play the role.
This is the first Simpsons episode to air after 9/11.