- After being mauled by a cunning wolf he has been tracking, and then robbed of his possessions by a stranger, MacKenzie is taken in by a homesteader and her son. The wolf, however, is still at large and MacKenzie is determined to kill him.
- While working a herd in the back country the Shiloh men led by Col. MacKenzie are threatened by a well-known wolf which has a $300 bounty as it has killed a man. While MacKenzie is on guard duty the wolf spooks the horses drawing him away from the herd. It then stampedes the cattle taking a calf for its effort. MacKenzie decides since he was on duty it is his job to track down and kill the sly wolf. The men including Tate warn him it is a dangerous and difficult hunt but having hunted tigers in India he is not overly concerned. On the road a posse tells him the Medicine Bow bank was robbed. Using a ham as bait he draws the attention of the wolf which attacks him first before taking the bait. With his arm wounded by the wolf, he trails it but soon falls sick from the wound and infection. A stranger on foot finds him offering help but instead steals MacKenzie's gun and horse. He cauterizes the wound. A young boy and his mother scare off the wolf and help him. Her husband is gone so he helps as payback and to continue the hunt as the wolf is tracking him. However, that turns out to not be the only threat.—Anonymous
- Colonel MacKenzie is out on a cattle drive with Tate and other ranch hands when a wolf sets off the steers. After the herd is settled a calf is heard bellowing in the distance followed by wolf howl.
The ranch hands warn Colonel MacKenzie that wolf hunting is dangerous but the Colonel insists he has hunted all his life, for many prey including tigers, so knows what he his doing.
Meanwhile back in town the bank has been robbed of seven thousand dollars and the town Sheriff meets Colonel MacKenzie on the trail and so the two hunters part company after their respective prey.
The Colonel is hunting the wolf using a trailing bait so but little does he realize the wolf is actually hunting him!
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