Cable's actions and motives are different in this episode compared to future appearances. In fact it suggests he's been in the present day for quite some time but there's no attempt to reconcile it with his later appearances where he's clearly a time traveler from the future. This may be the result of the series's writers being unaware of Marvel's plans for him. The first season aired 1992-1993, whereas Cable's origin wasn't confirmed in the comics until December 1993. Thus, the series writers likely adjusted to avoid any serious contradictions with the source material. Also of note, whereas there is no attempt to reconcile the two seasons' Cable appearances, the first season is not ignored. Rogue explicitly recalls her first encounter with Cable when the two battle in "Time Fugitives, Part 2." Being a time traveling commando however it can be explained away that his first appearance was him tracking down Apocalypse, who was central to that storyline.
Mutants seen held captive in various speaking and non speaking roles: Northstar, Aurora, Sunfire, Mystique, Rictor, Warpath, Blob, Feral, Domino, Pyro, and Avalanche. There is also a mutant in a red suit seen carrying a large object over his head that looks similar to Caliban. In Marvel comics, most of these Mutants were a part of "X-Force" - a "sister team" to the X-Men who served under Cable.
Northstar and Aurora of the Canadian super hero team Alpha Flight are among the captured mutants of Genosha. This marks these character's first appearance outside of the comics.
This episode features the first appearance of Cable outside of the comics.
Sunfire/Shiro Yashida, who is one of the mutant captives in Genosha, is featured without his traditional oversized domino mask that he wears in the comics.