Actress Michelle Trachtenberg was considered for an Emmy nomination due to her guest-starring role in this episode.
House's apartment is once again shown to be unit B of 221 Baker Street. This is a nod to Sherlock Holmes, who lived at 221 Baker Street in flat B.
At the end, when Wilson is watching TV, you hear Jimmy Stewart ask, "What is that doo-hickey?" and the response is "A brassiere." these are lines from the Hitchcock film Vertigo (1958). Wilson also has a Vertigo poster in his office.
When House talks about the clean room that the mom builds as being a Travolta style bubble, this is a reference to the 1976 TV movie The Boy in the Plastic Bubble. Travolta plays a boy that has immune deficiencies and needs to live inside a plastic bubble.