This episode along with the second parter are not available on HBO Max and South Park Studios' official website due to both episodes referencing the prophet Muhammad. Because of this, A Million Little Fibers (2006) was listed as Episode 3 in the playlist.
In 2012 Seth MacFarlane did an interview with Rolling Stone Magazine. In the interview, when asked about South Park, Seth MacFarlane would say that he thought the episode about Family Guy (1999) was funny yet he didn't understand the personal hatred that seemed to come his way from the South Park writers and creators.
Cameo: This episode received positive feedback from The Simpsons (1989) creator Matt Groening, and King of the Hill (1997) creator Mike Judge. Matt Groening liked it so much that flowers were sent to Trey and Matt. In the next episode, an imitation of the King of the Hill (1997) production building makes a cameo, joining the Bart Simpson likeness and arguably fulfilling the "Cartoon Wars" title.
This episode, along with Part II, addresses Matt and Trey's dislike for Family Guy (1999). Like Cartman, they dislike the show for the show's seemingly constant and random jokes, which bear little relevance to the plot of the episodes. However, they respect it for its fans and ability to generate a quick laugh, and still defend the show's constant desire to make light of any and all subjects, feeling that either everything should be open for mocking or nothing at all. On the DVD audio commentary, Parker states "we totally understand that people love it, that's why we put it in the show, we understand that it speaks to some people and it can just be a simple laugh and that's great and we certainly don't think it should be taken off the air or anything like that, we just don't respect it in terms of writing." He later refers to the writers behind the show as "smart" but emphatically criticizes their overuse of "gag-humor."
At the end, where the announcer asks, "Or will Comedy Central puss out," in regards to showing Muhammad, this is a reference to the fact that Comedy Central refused to allow Muhammad to be shown uncensored in this episode, despite requests from Matt and Trey.