- Dean has been framed for murder. Sam tries to find the one behind it.
- Sam and Dean investigate the murders of a lawyer and his wife who claimed to have seen a ghost right before they died. However, after local detectives Ballard and Sheridan uncover the Winchesters' records, they arrest the brothers for a double homicide before they are able to find the ghost. When the ghost begins to visit Ballard, she begins to wonder if the tale Sam and Dean are telling her could be true, and if she might be the next to die.—The CW
- In Baltimore, Maryland, Sam and Dean are arrested by the local police while investigating the murders of the lawyer Tony Giles and his wife Karen by a spirit. Detective Peter Sheridan is convinced that Dean is guilty while his partner and lover Detective Diana Ballard is aware that they just have circumstantial evidences against the Winchester brothers. Dean decides to tell the truth about the case, i.e., that Tony had seen and was killed by a vengeful spirit that wants justice, but nobody believes on his words. However, when Det. Ballard also sees the ghost of a woman with a sliced throat, she wonders whether Sam and Dean might be telling the truth. Together with Sam, Det. Ballard identifies the ghost as the heroine addicted Claire Becker, and Sam realizes that she is a death omen.—Claudio Carvalho, Rio de Janeiro, Brazil
- In Baltimore, Sam and Dean investigate the murder of a lawyer, Tony Giles, who was killed in his office, although the security cameras show no one either entering or leaving the room.
They interview his wife Karen, who reports that he had a nightmare or vision of a woman the night before he died. Breaking into his office, Sam and Dean find a printout with "danashulps" printed repeatedly on it, which they assume to be a name -- Dana Shulps. Sam stays to hack into the computer while Dean decides to return and ask Karen whether the name means anything. At her home, Karen sees a ghostly figure and rushes to call 911. When Dean arrives, he finds her dead in a pool of blood with a pile of paper near her which also has "danashulps" printed on it. As he bends over to examine bruises on her wrists, the police burst in and arrest him.
Sam is arrested at their motel room, and back at the police station the boys are interrogated separately. A lengthy police record has been uncovered for Dean, including suspicion of involvement in the murders in St. Louis, where he was reported as dead. Detective Diana Ballard interviews Sam, and he spins her a tale about Tony being an old friend of their father. Detective Ballard reveals she knows a lot about Sam's history as well, and tries to get him to admit Dean's involvement in the murders.
Detective Ballard leaves to confer with her colleague Detective Pete Sheridan, with whom she is having a relationship. Sheridan is convinced of Dean's guilt; he appears particularly invested in the case because Tony Giles was a friend of his. Dean's lawyer, Jeff Krause, arrives, but rather than speak to him Dean borrows a pen and tries to work out if "danashulps" is an anagram. His lawyer helps by pointing out that one word it forms, "Ashland", is a nearby street. Dean gets Jeff to take a coded note to Sam, passing on the information and telling him to escape.
Dean announces that he wants to confess, thus diverting all the police attention onto him. He doesn't confess to the murders, but says that he thinks a ghost is responsible and that the word "danashulps" is a message from her. Predictably, the police believe he is wasting their time, which he has been in order to allow Sam time to escape. Dean is cuffed and put in a cell.
Meanwhile, the word "danashulps" appears on Ballard's computer screen and she sees the ghostly figure of a woman with her throat slit. When she returns to speak to Dean, he see that bruises have appeared on her wrists similar to those he saw on Karen. He suspects she has seen something supernatural and tells her to go to Sam for help.
Together, she and Sam identify the woman she saw as Claire Becker, a heroin dealer who had worked as a police informant. She disappeared eight or nine months ago, but was last seen at 2911 Ashland Street. Sam explains to Diana that they need to find her body and salt and burn it in order to stop the killings.
While Sam and Diana are searching a building on Ashland, Claire appears again and points them to where they find her body hidden in a wall. Sam is bemused as to why the ghost would lead them to her body. Diana sees that Claire is wearing a distinctive necklace which is identical to one Pete has given her. Sam deduces that Claire is not a vengeful spirit, but a death omen who is trying to warn people who are about to be murdered.
Diana tells Sam that a couple of years ago some heroin went missing from the police lockup. She suspects that Pete stole it and used Claire to fence it. They suspect Pete is the murderer. Pete has taken Dean from the police station and driven out to the woods, intending to kill him. Sam and Diana track the car via its lo-jack and arrive just as Pete has a gun to Dean's head. He admits that he killed Claire because she was going to turn him in, and then killed Tony who had been involved in laundering the money and was getting nervous, and Karen because he suspected she knew too much. Pete tries to convince Diana that he can pin the crimes on Dean, but as he is about to shoot Dean, Diana shoots and wounds him. Pete disarms her, but the ghost of Claire appears and distracts him long enough for Diana to draw her backup gun and kill him. Diana agrees to let the boys go, telling them she will feel safer knowing they are out there fighting the supernatural.
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