Leonard Hofstadter and Sheldon Cooper are both brilliant physicists working at Caltech in Pasadena, California. They are colleagues, best friends, and roommates, although in all capacities their relationship is always tested primarily by Sheldon's regimented, deeply eccentric, and non-conventional ways. They are also friends with their Caltech colleagues mechanical engineer Howard Wolowitz and astrophysicist Rajesh Koothrappali. The foursome spend their time working on their individual work projects, playing video games, watching science-fiction movies, or reading comic books. As they are self-professed nerds, all have little or no luck with popular women. When Penny, a pretty woman and an aspiring actress originally from Omaha, moves into the apartment across the hall from Leonard and Sheldon's, Leonard has another aspiration in life, namely to get Penny to be his girlfriend. Written by
When beauty meets the brains.
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Did You Know?
Floors 2, 3, and 4 of Sheldon and Leonard's apartment building are the same set just re-dressed for each scene. This can be seen in the fact that the scuff marks on the moulding are identical on each level as they walk up the stairs. See more
The opening titles are based on a time line of human history. A picture of Abraham Lincoln is followed by a picture of George Washington. See more
[repeated line when someone calls Sheldon crazy
I'm not crazy! My mother had me tested.
One of the final cards to appear in the credit sequence is the vanity card for Chuck Lorre Productions. In keeping with his practice on "Dharma and Greg" and "Two and a Half Men", there is a different message on the card each week, written by Chuck Lorre himself. See more
Referenced in Survivor: Live Reunion Show