This is the first main game in the series that does not add new major characters to the over-sized roster.
The flag on top of Coco's house is a reference to the Canadian flag, only with the Crash paw print instead of the maple leaf. This is a reference to that Radical Entertainment is an Canadian company.
Tiny Tiger's type of species is changed in this game. In the games up to this point, Tiny was a Thylacine (aka Tasmanian Tiger). However, he was changed into a Siberian Tiger for this game. His personality was also altered.
This game originally was gonna be a new reboot of the franchise however due the bad criticism the second (Mind Over Mutant) would be the last game of them.