Natasha Little has appeared as two different characters over the course of the series:
- .Episode 11.5 Hippocratic Oath: Part 1 (2007) - Zoe McMorris
- .Episode 11.6 Hippocratic Oath: Part 2 (2007) - Zoe McMorris
- .Episode 21.9 Family: Part 1 (2018) - Alice Huston
- .Episode 21.10 Family: Part 2 (2018) - Alice Huston