The title is a play on the series God Friended Me (2018), which features Violett Beane, who played Jesse Wells in seasons 2 and 3, as Cara Bloom, one of the lead characters. The executive producer of that show, Greg Berlanti, is also executive producer/developer of all the Arrowverse shows.
In a reference to Supergirl now living on the same Earth as them, Chester says "Thank Rao!" at one point.
The merged form of Barry and Grodd, which grants Grodd access to the Speed Force and shows a lightning bolt painted on his chest, is a nod to Grodd's design following the New 52 reboot in 2011.
Cisco and Ralph are both absent, the former still on his fact-finding mission and the latter hunting down Sue. However, Cisco does call Kamilla to tell her he's coming home.
Solovar's first appearance in the series post-Crisis. In the original "Crisis" comics, Solovar is one of the individuals that Harbinger recruits to help stop the Anti-Monitor.