The beginning of the O. S. I. sequence parodies the opening of season one of G. I. Joe A Real American Hero
First appearance of Shore Leave
Before Dr. Girlfriend started arching with and dating The Phantom Limb she was his student at university. Also, he calls her by her first name, Sheila.
Pete White, working as The Quizboys game show host reveals that Billy Quizboy's actual last name is Whalen.
Written on chalkboard behind Professor Fantamos; "V.B. S3" (the 3 in superscript to denote cubed). This is a reference to Venture Brothers, season 3.