The game takes place just after the events of the movie.
There's two people who are easter egg kills, the firSt one is Wesley's girlfriend. She is in the first act looking out the window. The second is janice, Wesley's boss. she's in act four in one of the cubicles upstairs. if you shoot wesley's girlfriend, the xbox achievement "half the man barry is", which is a quote she says to wesley in the movie, and when you shoot janice the achievement is "kill one, save a thousand doughnuts"
The killer outfit is not from the movie but is from the comic books