This is the first episode of the series not to conclude with an instrumental version of the theme song known as "Mighty Little Man," by Steve Burns.
When Sheldon's sister, Missy, is watching TV, the show she is watching is Are You Afraid of the Dark? (1990), featuring the recurring character of Dr. Vink. "Are You Afraid of the Dark" was a very popular show during the time period this episode of "Young Sheldon" takes place.
George says, "Balls," repeatedly at the beginning of the episode when he is interrupted. This is paying homage to the fact that on the The Big Bang Theory (2007) bloopers reels, the cast says "Balls" when they make a mistake.