Near the end of the episode, Penny's father is begging Leonard to not give up on Penny. He says that he wants "grandkids" before he dies. However, he already has at least one grandson. In season 2, episode 20, The Hofstadter Isotope, Penny goes to the comic book store looking for a birthday present for her 13-year-old nephew.
Penny's father is called "Wyatt" here, even though Penny stated in The Maternal Capacitance (2009) that her mother calls him "Bob". It can be assumed that 'Bob' or 'Robert' is Wyatt's second name, or how his wife calls him.
Sheldon claims the bravest man in the Marvel Universe is the doctor who gives Wolverine his prostate exam. However Wolverine's superpower is a healing factor, rendering him immune to all forms of injury and illness, so he wouldn't actually ever need a prostate exam.