Bad Larry is in the final scene even though Stan accidentally killed him in "The 42-Year-Old Virgin" in season 3.
The episode makes a reference to film actress Beverly Billingsley, who actually died about three months before the episode aired. That's Barbara Billingsley. There is no actress named Beverly Billingsley.
Francine states in one scene that feels as gross "as the tattoo on Aida Turturro's left boob."
The title is the nicknames given to Stan and Francine during the episode.
Stan reveals one of his school nicknames was Stan Frank for hiding and writing in a diary. A reference to The Diary of Anne Frank.