While Rooker in the game was part of a film directed by Romero, Michael Rooker had actually been directed by George A. Romero before in The Dark Half (1993).
All four main playable characters in the game, Michael Rooker, Danny Trejo, Robert Englund, and Sarah Michelle Geller have all been in zombie related media previously. Trejo in Zombie Hunter and Rise of the Zombies. Rooker on The Walking Dead TV show. Geller in Buffy The Vampire Slayer. Englund in Zombie Strippers.
First map in Call of Duty's Zombies mode to have beginning and ending cutscenes.
In an interview with the Zombie Research Society, George A. Romero was asked if he recorded motion-capture for his character in Call of the Dead, to which he replied, "I didn't. I wish that I would have! They didn't use my voice. They wound up not using anything of me. Except my face." This contrasts with the other four actors, who all provided their voice and performed motion-capture for the intro.