The body temperature that Mr. Clarke can sustain is too low for a man to be able to take and still be able to move.
In the conning tower mission, Edwards' voice says '...you can't kill electricity.' However, the subtitles say '...you can't shoot what you can't see.'
Grammar mistakes in subtitles.
Spelling mistakes in subtitles.
Guns eject shells even though they are using energy.
Most of the air locks seem to vent into space instead of equalizing pressure. This is extremely inefficient as it can rapidly deplete oxygen supplies. It is unlikely that any airlock would use this system.
In the snow suit instructions it is stated that a small tear in the suit can cause death in less than a minute from the cold, yet Mr. Clarke can stand several minutes in the cold in a damaged suit with no helmet.
The winch cable doesn't move while it is on.
The suits available on the surface of the lanes have thrusters. These are older suit models than the ones Mr. Clarke uses in Dead Space, which didn't have thrusters.
The weapons used in the prologue set 200 years in the past are also used in the present time 200 years in the future, despite other designs of the weapons and ammunition systems being in use earlier in the first 2 games.
The soldier in the prologue only starts with an empty gun. It is not explained why a soldier is issued an empty weapon.
Despite being over 200 years old, the ammunition found near and on the ice world can still be used in modern weapons that are more advanced.
In between scripted events in space, Mr. Clarke's air supply replenishes for no reason.
Despite some ships in the fleet sustaining massively catastrophic damage, there is still power to most parts after 200 years.
On the Lunar colony, the Players get ambushed. The leader of the enemies says 'Take them out' even if there is only one Player.
The enemy troops are using an unencrypted channel.