Claire and annie change their clothes again, making them the only characters on the show who constantly change their clothes.
The title "Hermanos" means "Brothers" in Spanish.
This episode marks Annie's first appearance in season three.
Hermanos was supposed to be the last Generator Rex filler episode, so that both the first and the last filler episodes includeed Claire and Annie.
Rex describes Noah, Claire, and Annie as his real family. This is similar to what happened at the end of mixed signals when he described Agent Six ,Holiday and bobo as his real family.