Bruce Campbell and Stan Lee are the only two returning cast members in the video game that were from the previous Spiderman movies and/or games.
In a special DLC for the game, you can play as Spider-Man co-creator Stan Lee. He loses pages for his next comic book script and must get them back. And the end credits is a parade of all of the characters dancing and celebrating 50 years of Spider-Man.
The game takes place directly after the events of The Amazing Spider-Man (2012) and features spoilers for the film.