The segment "The Box" is the only one of the four segments that is not actually an original story by the women but is instead an adaptation of the Jack Ketchum story.
Danny Elfman's taxidermy cat Frisky makes a cameo in the segment "The Birthday Party" (when he is turned to be adjusted).
Directorial debut of musician and songwriter St. Vincent, who goes by her birth name Annie Clark for the film, and Jovanka Vuckovic.
The title of the film, XX, is a reference to the chromosomes that determine the genetic make up for a woman, a reference to the female dominant crew behind the production of these short films.
Antonia Bird was originally in talks to direct a segment before her passing. The film is dedicated to her memory.