It is mentioned that Frankie once impulse bought an alpaca. This is a reference to Lily Tomlin's character in The West Wing, who was a failed alpaca farmer before being asked to work for Martin Sheen's character, President Bartlet.
During a restaurant scene, Grace (Jane Fonda) says of estranged husband Robert (Martin Sheen) that, "He's always been afraid of Irish women. His mother was Irish." Sheen's real-life mother was actually Irish.