All 8 members of the cluster were born on August 8th, or "8/8"
This episode's title plays such a profound part in the plot and back stories of quite a few of the characters. It also captures a couple other characters fears as they sit beside a loved one's hospital bed. When Riley is reminiscing about her past, she says to Capheus, "Death doesn't let you say goodbye," she goes on further to explain, "it just carved holes in your life...your future...in your heart."
At the start, when Lito is having a drink at the bar, you can here the intro music playing on a guitar.