At approximately 10:00 minutes Cat Grant says, "Kiera, call Harrison Ford and tell him I'm flattered, but once and for all, I do not date older men, especially when they're married." Harrison Ford is not only married to Calista Flockhart, but when they started dating in 2002, he was 60 and she was just 38. And Harrison Ford was married (to his second wife; that marriage ended in Jan 2004).At the time, this was very big news and much was made of their 22 year age difference. Many expected that the large age difference would result in a short-lived relationship. Therefore, this may not only be an inside joke, but also a bit of a tongue in cheek 'I told you so' to the tabloids.
Helen Slater (Eliza Danvers) and Laura Vandervoort (Indigo) have both played Supergirl themselves: Slater in Supergirl (1984) and Vandervoort in Smallville (2001). They previously worked together in Lara (2007) and Blue (2007).
The town Midvale is mentioned. In the comics, when Supergirl first arrived on Earth, Superman placed her in Midvale Orphanage under the name Linda Lee. She became Linda Lee Danvers some years later, when she was adopted by the Danvers family.
Kara is grossed out when Maxima mentions she once tried to make Superman her mate. When the Maxima character, played by Charlotte Sullivan, appeared on Smallville (2001) in "Instinct (2008)", she pursued Clark, believing him to be her soul mate.