There is a hidden A113 in the hallway at the beginning, A113 is a common Easter egg found in Disney or Pixar films
The title is a reference to The Life Aquatic with Steve Zissou
The water polo coach who repeatedly insists that he is not James Hetfield from Metallica is, of course, voiced by James Hetfield from Metallica.
Ashley Tisdale's guest role here makes Vincent Martella the only one of the 3 main cast members of Phineas and Ferb (2007) who has not been in American Dad yet.