- Ed interviews a lab mouse. Bruce Dern (Coming Home (1978)); Robert Klein (Hooper (1978)); Susan Sullivan (Having Babies (1978)); Dr. Carl Sagan discusses extraterrestrial life.
- The comedy segment is Ed's interview with a lab mouse about the tests it is subjected to. Johnny doesn't have time to change out of costume, so he does the first half of Bruce Dern's interview dressed in the mouse costume. Dern recalls how he was never paid his $1,700 salary for the movie "The Incredible 2-Headed Transplant", which was filmed in six days, since the crew got to the bank during filming while the actors were busy, and the producer only deposited $5,000 to cover $17,000 in checks; by the following Monday, county sheriffs had closed down the production site. Dern then talks about his new film "Coming Home", and contrasts his activity during the Vietnam War with the activism of his co-stars Jane Fonda and Jon Voight; he also comments on reactions toward veterans of the war, and the attitudes of those who chose to serve rather than evade the draft; a clip is shown. He then talks about how the success of the film has helped his career with many more offers, and a chance to be the leading man instead of the villain. He lists several stars (including Ann-Margret, Rock Hudson and Ralph Bellamy) from his wealthy hometown north of Chicago, where the high school had no drama program. Robert Klein does not do a stand-up routine, but in his interview he discusses "Hooper", the film he is working on with Burt Reynolds, and seeing the stuntmen work. He also talks about filming in Tuscaloosa, Alabama. Susan Sullivan talks about having worked in the NY Playboy Club while in college, and comments on differing opinions within feminism. She also talks about playing a gynecologist in her new series "Having Babies". Dr. Carl Sagan is the next guest. Johnny asks him about the scientific validity of films such as "Star Wars" and "Close Encounters", and he comments that certain things are mistakes, such as the possibility of human life evolving independently in a distant galaxy. He discusses the use of the term "parsec" in terms of distance versus time, and explains that the scientific understanding of the universe only works if it is not possible to exceed the speed of light. Sagan then discusses the project to search for signs of other intelligence in the universe, how we would recognize it, and why it would be valuable even though the vast distances involved would limit communication.—lenab9011
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