When the children together play a video game identified only as "GTA" on a video game console identified only as "Xbox", gameplay from the Enhanced Edition of "Grand Theft Auto V" is shown. This carries the implication that whatever particular video game they are playing is somewhat different from the actual "Grand Theft Auto V" despite having the same assets including the setting. So, in a sense, the children are playing a version of "Grand Theft Auto V" that accommodates more than one player in Story Mode. In a competitive match of some kind within such a mode, one of the children controls Michael De Santa while the other apparently controls either a Los Santos police officer or an off-screen protagonist of the video game. In reality, no official version of the particular video game accommodates such gameplay. This barely-noticeable element of artistic license is somewhat instrumental to the fictional story of "My Brother Wes", and while it may inadvertently misrepresent "Grand Theft Auto V", some equivalents of the gaming experience as depicted are somethings that actual hackers have been able to achieve without even patching the source code of the video game.
In this short movie, the video game "GTA" serves as an allegory for crime-themed video games in general, and how anxious children can easily fail to grasp the full context of these works of entertainment, since conversely the actual gameplay that corresponds to the particular installment of the "Grand Theft Auto" series portrayed in the movie carries many satirical exaggerated themes of just how excruciatingly harsh the consequences of somebody even so much as wielding a firearm in a threatening manner are. Notably, in Los Santos, a fictional city in the "Grand Theft Auto" HD universe, some cashiers are quietly armed and use the fact that a robber (a player-controlled character) has turned his back on them as the opportunity to gun down the robber before he has a chance to escape. Of course, unlike the virtual world, dead people cannot respawn alive and uninjured at the hospital.